Browsing Experimentally Confirmed database

Result: Your query found 31 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
acrA
  • BacMet ID: BAC0005
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 397
  • Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    acrB
  • BacMet ID: BAC0006
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 1049
  • Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    mepB
  • BacMet ID: BAC0222
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump membrane transporter MepB; the inner membrane transporter component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 1050
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

    		• Similar resistance genes in 'BacMet Predicted database'
    mepC
  • BacMet ID: BAC0223
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons] [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump outer membrane protein MepC; the outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 484
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

    		• Similar resistance genes in 'BacMet Predicted database'
    mexA
  • BacMet ID: BAC0234
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.
  • Length (amino acid): 383
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexB
  • BacMet ID: BAC0235
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.
  • Length (amino acid): 1046
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexC
  • BacMet ID: BAC0236
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 387
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexD
  • BacMet ID: BAC0237
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 1042
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexE
  • BacMet ID: BAC0238
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas entomophila (strain L48)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 413
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexF
  • BacMet ID: BAC0239
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 1059
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    oprJ
  • BacMet ID: BAC0291
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon.
  • Length (amino acid): 479
  • Reference: Li et al. 1998; Pubmed- 9603892, Poole et al. 1996; Pubmed- 8878035

    		• Similar resistance genes in 'BacMet Predicted database'
    oprM/oprK
  • BacMet ID: BAC0292
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter
  • Length (amino acid): 485
  • Reference: Li et al. 1995; Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    oprN
  • BacMet ID: BAC0562
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa.
  • Length (amino acid): 472
  • Reference: Li et al. 1998; Pubmed- 9603892, Kohler et al. 1997; Pubmed- 9044268

    		• Similar resistance genes in 'BacMet Predicted database'
    srpA
  • BacMet ID: BAC0372
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump periplasmic linker SrpA; a component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon Expression level.
  • Length (amino acid): 382
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpB
  • BacMet ID: BAC0373
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant pump membrane transporter SrpB; The inner membrane transporter component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 1049
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpC
  • BacMet ID: BAC0374
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump outer membrane protein SrpC; The outer membrane component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 470
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpR
  • BacMet ID: BAC0375
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpR; In conjunction with SrpS represses the srpABC operon.
  • Length (amino acid): 213
  • Reference: Sun et al. 2011; Pubmed- 21441510

    		• Similar resistance genes in 'BacMet Predicted database'
    srpS
  • BacMet ID: BAC0376
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpS; In conjunction with SrpR represses the srpABC operon.
  • Length (amino acid): 259
  • Reference: Sun et al. 2011; Pubmed- 21441510

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgA
  • BacMet ID: BAC0404
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump periplasmic linker protein TtgA; The periplasmic linker protein component of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 384
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgB
  • BacMet ID: BAC0405
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The inner membrane transporter component, ttgB of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 1050
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgC
  • BacMet ID: BAC0406
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The outer membrane component ttgC of a constitutive organic solvent efflux system ttgABC. Is involved in Export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 484
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgD
  • BacMet ID: BAC0407
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The periplasmic linker protein component, ttgD of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux
  • Length (amino acid): 382
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgE
  • BacMet ID: BAC0408
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The inner membrane transporter component, ttgE of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.
  • Length (amino acid): 1046
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgF
  • BacMet ID: BAC0409
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The outer membrane component, ttgF of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.
  • Length (amino acid): 480
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgG
  • BacMet ID: BAC0410
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The periplasmic linker component ttgG, of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.
  • Length (amino acid): 391
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgH
  • BacMet ID: BAC0411
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The inner membrane transporter component, ttgH of an organic solvent efflux pump ttgGHI. Involved in Export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics
  • Length (amino acid): 1049
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgI
  • BacMet ID: BAC0412
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The outer membrane component, ttgI of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.
  • Length (amino acid): 470
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgR
  • BacMet ID: BAC0413
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump ttgABC operon repressor ttgR; Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.
  • Length (amino acid): 210
  • Reference: Duque et al. 2001; Pubmed- 11251828, Teran et al. 2003; Pubmed- 14506010, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgT
  • BacMet ID: BAC0414
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: Regulator of the ttgDEF efflux pump ttgT; Can regulate the ttgDEF system expression in ttgV-deficient condition; effect of TtgT on ttgGHI Expression is not obvious when TtgV is present but becomes relevant in its absence
  • Length (amino acid): 260
  • Reference: Teran et al. 2007; Pubmed- 17986203, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgV
  • BacMet ID: BAC0415
  • Code for: Regulator
  • Family: Isocitrate lyase regulator (IclR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: HTH-type transcriptional regulator TtgV; Represses the expression of the ttgGHI and ttgVW operons. Binds to the ttgGHI / ttgVW intergenic region, probably preventing binding of RNA polymerase; ttgV dissociates from this region in the presence of 1-hexanol, can regulate the ttgDEF expression as well; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin
  • Length (amino acid): 259
  • Reference: Teran et al. 2007; Pubmed- 17986203, Rojas et al. 2003; Pubmed- 12896994, Rodriguez-Herva et al. 2007; Pubmed- 17504492

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgW
  • BacMet ID: BAC0416
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: HTH-type transcriptional regulator TtgW; does not seem to be involved in regulation of the ttgGHI or ttgVW operons; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin
  • Length (amino acid): 134
  • Reference: Rojas et al. 2003; Pubmed- 12896994, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
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